Chang Hsiu-Hao, Lu Meng-Yao, Jou Shiann-Tarng, Lin Kai-Hsin, Tien Hwei-Fang, Lin Dong-Tsamn
Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
Pediatr Hematol Oncol. 2006 Sep;23(6):495-506. doi: 10.1080/08880010600739368.
The aim of the study was to define the frequency and types of acquired chromosomal aberrations in a group of Taiwanese children with ALL. The sample population consisted of 78 patients under 18 years of age with newly diagnosed ALL who underwent cytogenetic studies at diagnosis and had adequate metaphase chromosomes for analysis at the authors' hospital from 1993 to 2001. Metaphase chromosomes were banded using the conventional trypsin-Giemsa banding technique. Analysis of ploidy revealed 16 (20.5%) patients with normal diploidy, 28 (35.9%) with pseudodiploidy, 6 (7.7%) with hyperdiploidy (47-50), 19 (24.4%) with hyperdiploidy (> 50), and 9 (9.4%) hypodiploidy. Near-haploidy was not observed. Of the patients with abnormal karyotypes, recurrent structural abnormalities were determined in 31 (50%) cases, with the most frequent t(9;22). In conclusion, the frequency and type of acquired chromosomal aberrations found in these Taiwanese children with ALL are similar to those reported in the literature.
本研究的目的是确定一组台湾急性淋巴细胞白血病(ALL)患儿获得性染色体畸变的频率和类型。样本群体包括78例18岁以下新诊断为ALL的患者,他们于1993年至2001年在作者所在医院诊断时接受了细胞遗传学研究,且有足够的中期染色体用于分析。中期染色体采用传统的胰蛋白酶-吉姆萨显带技术进行显带。倍性分析显示,16例(20.5%)患者为正常二倍体,28例(35.9%)为假二倍体,6例(7.7%)为超二倍体(47 - 50条染色体),19例(24.4%)为超二倍体(>50条染色体),9例(9.4%)为亚二倍体。未观察到近单倍体。在核型异常的患者中,31例(50%)检测到复发性结构异常,最常见的是t(9;22)。总之,这些台湾ALL患儿中获得性染色体畸变的频率和类型与文献报道相似。