Petrulis A S, Imperiale T F, Speroff T
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio.
J Gen Intern Med. 1991 Nov-Dec;6(6):503-6. doi: 10.1007/BF02598217.
To determine the acute effect of phenylpropanolamine, 75 mg, and brompheniramine, 12 mg, in combination (PPA/B) on blood pressure in patients with controlled hypertension, using ambulatory blood pressure monitoring (ABPM).
Randomized double-blind crossover trial.
Outpatient clinic at one medical center.
13 healthy volunteers aged 36 to 64 years, receiving medication for hypertension.
Following 24-hour baseline ABPM, participants were randomized to receive either placebo or PPA/B every 12 hours for three doses, while ABPM continued. After a 24-hour washout period, all participants received the crossover regimen.
No clinically important or statistically significant difference was noted for mean systolic and diastolic blood pressures during the baseline (125/75), PPA/B (127/72), and placebo (126/73) phases of the study. Within the first four hours of treatment, the mean change in systolic blood pressure from baseline between PPA/B and placebo phases was 1.7 mm Hg (95% CI -5.3 to 8.7), and mean change in diastolic blood pressure was 0.9 mm Hg (95% CI -1.6 to 3.5), excluding a first-dose pressor effect.
When used as recommended, PPA/B, a commonly used over-the-counter cold medication, has no significant acute effect on blood pressure in patients with controlled hypertension.
采用动态血压监测（ABPM），确定75毫克苯丙醇胺与12毫克溴苯那敏联合使用（PPA/B）对血压得到控制的高血压患者血压的急性影响。
随机双盲交叉试验。
某医疗中心的门诊诊所。
13名年龄在36至64岁之间、正在接受高血压治疗的健康志愿者。
在进行24小时基线ABPM后，参与者被随机分组，每12小时接受一次安慰剂或PPA/B，共三剂，同时继续进行ABPM。经过24小时的洗脱期后，所有参与者接受交叉治疗方案。
在研究的基线期（125/75）、PPA/B期（127/72）和安慰剂期（126/73），平均收缩压和舒张压均未观察到具有临床意义或统计学意义的差异。在治疗的前四小时内，PPA/B期与安慰剂期相比，收缩压自基线的平均变化为1.7毫米汞柱（95%置信区间-5.3至8.7），舒张压的平均变化为0.9毫米汞柱（95%置信区间-1.6至3.5），排除首剂升压效应。
按照推荐使用时，常用的非处方感冒药PPA/B对血压得到控制的高血压患者的血压无显著急性影响。
