Evaluation of alpha-adrenoceptor agonistic activity of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in rabbit and rat aortae.

The alpha-adrenergic activity of a dopamine receptor agonist, 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127), has been studied on isolated rabbit and rat aortic strips. In both tissues, RDS-127 produced concentration-dependent contractions and its potency was not significantly different from that of phenylephrine. RDS-127-induced contractions were antagonized competitively by both prazosin and phentolamine in rabbit aortic strips, but the antagonists were noncompetitive in rat aortic strips.