Antus Balazs, Fillinger Janos, Sebe Attila, Jeney Csaba, Soltesz Ibolya, Horvath Ildiko
Department of Pathophysiology, National Koranyi Institute for TB and Pulmonology, Pihenö Street 1, H-1529 Budapest, Hungary.
Exp Mol Pathol. 2006 Dec;81(3):235-8. doi: 10.1016/j.yexmp.2006.06.002. Epub 2006 Jul 21.
The aim of this study was to test whether donor and recipient gender influence the development of obliterative airway disease in an established rat model of human bronchiolitis obliterans. Rat tracheas were transplanted from male and female Brown-Norway donors into male and female Lewis recipients. Grafts were harvested at days 7, 14 and 21 for morphometric studies and molecular analysis by real-time PCR. At each time point, both epithelial injury and the extent of luminal occlusion of the tracheal allografts were similar between the groups. Furthermore, intragraft mRNA expression for transforming growth factor (TGF)-beta1, interleukin (IL)-2 and interferon (INF)-gamma did not differ between the groups. Our data suggest that gender has no impact on the development of obliterative airway disease in this transplant model.
本研究的目的是在已建立的人类闭塞性细支气管炎大鼠模型中，测试供体和受体的性别是否会影响闭塞性气道疾病的发展。将雄性和雌性布朗 - 挪威大鼠的气管移植到雄性和雌性刘易斯大鼠体内。在第7、14和21天采集移植物，用于形态计量学研究和通过实时PCR进行分子分析。在每个时间点，各组之间气管同种异体移植物的上皮损伤和管腔闭塞程度均相似。此外，各组之间移植物内转化生长因子（TGF）-β1、白细胞介素（IL）-2和干扰素（INF）-γ的mRNA表达没有差异。我们的数据表明，在该移植模型中，性别对闭塞性气道疾病的发展没有影响。
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