人类胰腺中端粒随衰老而缩短。
Telomere shortening with aging in the human pancreas.
作者信息
Ishii Akio, Nakamura Ken-Ichi, Kishimoto Hiroshi, Honma Naoko, Aida Junko, Sawabe Motoji, Arai Tomio, Fujiwara Mutsunori, Takeuchi Fujio, Kato Motonobu, Oshimura Mitsuo, Izumiyama Naotaka, Takubo Kaiyo
机构信息
Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015, Japan.
出版信息
Exp Gerontol. 2006 Sep;41(9):882-6. doi: 10.1016/j.exger.2006.06.036. Epub 2006 Jul 24.
We have conducted systematic studies to measure telomere length in human tissues of all types. Progressive telomere shortening with aging was studied in specimens of normal pancreas obtained at autopsy from 69 subjects aged 0 to 100 yr, and age-related shortening of telomere length at a rate of 36 base pairs (bp) per year was detected. Mean telomere length (+/-SD) was 13.9+/-1.4 kilobase pairs (kbp) in 16 neonates, as opposed to 8.4 kbp in 2 centenarians. Mean telomere length (+/-SD) in four age groups, 0-24, 25-49, 50-74, and 75-100 yr, was 13.5+/-1.5, 12.3+/-0.7, 11.3+/-2.5, and 10.7+/-1.8, respectively.
我们开展了系统性研究，以测量所有类型人体组织中的端粒长度。在从69名年龄在0至100岁的受试者尸检中获取的正常胰腺标本中，研究了随着衰老端粒长度的逐渐缩短情况，检测到端粒长度每年以36个碱基对（bp）的速率出现与年龄相关的缩短。16名新生儿的平均端粒长度（±标准差）为13.9±1.4千碱基对（kbp），而2名百岁老人的平均端粒长度为8.4 kbp。四个年龄组（0 - 24岁、25 - 49岁、50 - 74岁和75 - 100岁）的平均端粒长度（±标准差）分别为13.5±1.5、12.3±0.7、11.3±2.5和10.7±1.8。
Zotero 插件