细胞周期：持续的细胞外信号调节激酶信号传导会抑制这些抑制剂。

Cell cycle: sustained ERK signalling represses the inhibitors.

作者信息

Sharrocks Andrew D

机构信息

Faculty of Life Sciences, University of Manchester, UK.

出版信息

Curr Biol. 2006 Jul 25;16(14):R540-2. doi: 10.1016/j.cub.2006.06.038.

DOI:10.1016/j.cub.2006.06.038

PMID:16860730

Abstract

The duration of ERK pathway signalling determines the proliferative response of cells. A recent study has shown that cell cycle re-entry requires the downregulation of an anti-proliferative gene cluster following sustained activation of the ERK pathway.

摘要

ERK信号通路的持续时间决定细胞的增殖反应。最近一项研究表明，细胞周期重新进入需要在ERK通路持续激活后下调一个抗增殖基因簇。