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端粒保护:天意使然。

Telomere protection: an act of God.

作者信息

Szilard Rachel K, Durocher Daniel

机构信息

Centre for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

出版信息

Curr Biol. 2006 Jul 25;16(14):R544-6. doi: 10.1016/j.cub.2006.06.037.

Abstract

Telomeres are nucleoprotein structures that shelter the ends of linear chromosomes from being inappropriately recognized as DNA double-strand breaks. New work has revealed that Apollo, a nuclease previously implicated in DNA repair, also has a role in safeguarding telomeres during S phase.

摘要

端粒是一种核蛋白结构,可保护线性染色体的末端不被错误地识别为DNA双链断裂。新的研究表明,Apollo(一种先前与DNA修复有关的核酸酶)在S期保护端粒方面也发挥着作用。

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