Szilard Rachel K, Durocher Daniel
Centre for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
Curr Biol. 2006 Jul 25;16(14):R544-6. doi: 10.1016/j.cub.2006.06.037.
Telomeres are nucleoprotein structures that shelter the ends of linear chromosomes from being inappropriately recognized as DNA double-strand breaks. New work has revealed that Apollo, a nuclease previously implicated in DNA repair, also has a role in safeguarding telomeres during S phase.
端粒是一种核蛋白结构,可保护线性染色体的末端不被错误地识别为DNA双链断裂。新的研究表明,Apollo(一种先前与DNA修复有关的核酸酶)在S期保护端粒方面也发挥着作用。