Parmar K A, Rao S, Abu-Zidan F M
Department of Emergency Medicine, Royal Perth Hospital, Perth, Western Australia.
Singapore Med J. 2006 Aug;47(8):676-8.
The objective of this study was to study the clinical course and outcome of warfarinised patients who were hospitalised because of head trauma.
13 patients (ten males and three females; median age 69 years) who presented to the Royal Perth Hospital, Australia and who had suffered a head injury between July 1994 and June 2000 while concurrently taking warfarin, were studied.
Confusion was the commonest presenting symptom (four patients). Five patients presented after more than 24 hours of the injury. Eight patients were anticoagulated for thromboembolic disease and five for atrial fibrillation. The patients had a median injury severity score of 25 (range 1-43). The median international normalised ratio was 2.4 (range 1.8-10) on admission and 1.8 (range 1.0-10) on discharge. 11 of the 13 patients had computed tomography of the head. Intracerebral bleeding was the commonest injury (nine patients). The median length of hospital stay was six days (range 3-30). Five patients died (38.5%).
Warfarinised patients who sustain minor head trauma should be hospitalised for close neurological observation and should have a low threshold for performing computed tomography.
本研究的目的是探讨因头部外伤住院的华法林治疗患者的临床病程及预后。
对1994年7月至2000年6月期间在澳大利亚皇家珀斯医院就诊、头部受伤且同时服用华法林的13例患者(10例男性,3例女性;中位年龄69岁)进行研究。
意识模糊是最常见的症状(4例患者)。5例患者在受伤24小时后就诊。8例患者因血栓栓塞性疾病接受抗凝治疗,5例因心房颤动接受抗凝治疗。患者的中位损伤严重程度评分为25分(范围1 - 43分)。入院时国际标准化比值的中位数为2.4(范围1.8 - 10),出院时为1.8(范围1.0 - 10)。13例患者中有11例进行了头部计算机断层扫描。脑内出血是最常见的损伤(9例患者)。住院时间的中位数为6天(范围3 - 30天)。5例患者死亡(38.5%)。
头部受轻伤的华法林治疗患者应住院接受密切的神经学观察,且进行计算机断层扫描的阈值应较低。