Kieffer Nelly, Schmitz Martine, Scheiden René, Nathan Michel, Faber Jean-Claude
Laboratoire de Biologie et Physiologie Intégrée (CNRS/GDRE-ITI), Université du Luxembourg.
Bull Soc Sci Med Grand Duche Luxemb. 2006(1):21-8.
Prostate cancer is one of the most common cancers among men and has long been recognized to occur in familial clusters. Identification of genetic susceptibility loci for prostate cancer has however been extremely difficult, and only in 1996 was the first prostate cancer susceptibility locus HPC1 mapped to chromosome 1q24-25. Since, several additional putative loci have been identified by genetic linkage analysis on chromosome 1, 17, 20 and X (reviewed in). For three of these loci, family-based studies have identified three genes associated with inherited prostate cancer: the 3' processing endoribonuclease ELAC2/HPC2 gene, the macrophage scavenger receptor 1 gene (MSR1), and the endoribonuclease RNase L gene (RNAse L/HPC1). Here we will focus our review on the RNAse L gene and its involvement in prostate cancer and other diseases.
前列腺癌是男性中最常见的癌症之一，长期以来人们一直认识到它会在家族中聚集发生。然而，鉴定前列腺癌的遗传易感性位点极其困难，直到1996年，首个前列腺癌易感位点HPC1才被定位到1号染色体的1q24 - 25区域。此后，通过对1号、17号、20号染色体和X染色体的遗传连锁分析，又鉴定出了几个其他的假定位点（相关综述见）。对于其中三个位点，基于家族的研究已经确定了三个与遗传性前列腺癌相关的基因：3'加工核糖核酸内切酶ELAC2/HPC2基因、巨噬细胞清道夫受体1基因（MSR1）和核糖核酸内切酶RNase L基因（RNAse L/HPC1）。在这里，我们将把综述重点放在RNase L基因及其在前列腺癌和其他疾病中的作用上。
