多巴胺D1和D2受体在介导右旋苯丙胺辨别性线索中的作用。
Role of dopamine D1 and D2 receptors in mediating the d-amphetamine discriminative cue.
作者信息
Furmidge L J, Exner M, Clark D
机构信息
Neuropsychopharmacology Laboratory, Department of Psychology, University of Reading, U.K.
出版信息
Eur J Pharmacol. 1991 Sep 17;202(2):191-9. doi: 10.1016/0014-2999(91)90294-z.
The role of D1 and D2 dopamine (DA) receptors in mediating the discriminative cue produced by d-amphetamine (0.5 mg/kg) in rats has been assessed by using compounds which exert strong selectivity for each of these DA receptor subtypes. The D2 agonists quinpirole and RU 24213 substituted completely for d-amphetamine, while the D1 agonists SKF 38393 and SKF 81297 failed to exert such effects. On the other hand, the D2 antagonists raclopride and YM 09151-2, and D1 antagonists SCH 23390 and SKF 83566, all completely blocked d-amphetamine discrimination. The D2 antagonists produced more pronounced inhibitory effects on response rate than did D1 antagonists. Quinpirole substitution for d-amphetamine was blocked by YM 09151-2, but not by SCH 23390, while the locomotor stimulatory effect of quinpirole was inhibited by both drugs. The present findings confirm that D2 receptors play a primary role in the d-amphetamine discriminative cue, while the precise role of D1 receptors remains to be disclosed.
通过使用对这些多巴胺（DA）受体亚型具有高度选择性的化合物，评估了D1和D2多巴胺（DA）受体在介导大鼠中由右旋苯丙胺（0.5mg/kg）产生的辨别性线索中的作用。D2激动剂喹吡罗和RU 24213完全替代了右旋苯丙胺，而D1激动剂SKF 38393和SKF 81297未能产生此类作用。另一方面，D2拮抗剂雷氯必利和YM 09151-2以及D1拮抗剂SCH 23390和SKF 83566均完全阻断了右旋苯丙胺辨别。D2拮抗剂对反应率产生的抑制作用比D1拮抗剂更明显。喹吡罗替代右旋苯丙胺被YM 09151-2阻断，但未被SCH 23390阻断，而喹吡罗的运动刺激作用被两种药物均抑制。目前的研究结果证实，D2受体在右旋苯丙胺辨别性线索中起主要作用，而D1受体的确切作用仍有待揭示。
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