FOXP3与NFAT：免疫耐受中的伙伴关系。

FOXP3 and NFAT: partners in tolerance.

作者信息

Rudensky Alexander Y, Gavin Marc, Zheng Ye

机构信息

Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98195, USA.

出版信息

Cell. 2006 Jul 28;126(2):253-6. doi: 10.1016/j.cell.2006.07.005.

DOI:10.1016/j.cell.2006.07.005

PMID:16873058

Abstract

Regulatory T cells suppress autoimmune responses to self-antigens. Recent studies, including one in this issue of Cell (Wu et al., 2006), suggest that the ability of T cells to choose between launching a productive immune response, functional inactivation, or developing into regulatory T cells depends upon the interplay of the key transcriptional regulators FOXP3 and NFAT.

摘要

调节性T细胞可抑制针对自身抗原的自身免疫反应。包括本期《细胞》杂志上发表的一项研究（Wu等人，2006年）在内的近期研究表明，T细胞在启动有效的免疫反应、功能失活或发育为调节性T细胞之间进行选择的能力，取决于关键转录调节因子FOXP3和NFAT之间的相互作用。