[阿伏苯唑对具有不同情绪应激反应表型的近交系小鼠脑结构中脑源性神经营养因子含量的影响]
[Effects of afobazole on the BDNF content in brain structures of inbred mice with different phenotypes of emotional stress reaction].
作者信息
Seredin S B, Melkumian D S, Val'dman E A, Iarkova M A, Seredina T C, Voronin M V, Lapitskaia A S
出版信息
Eksp Klin Farmakol. 2006 May-Jun;69(3):3-6.
Changes in the BDNF content in brain structures--hippocampus, hypothalamus, striatum, and frontal cortex--were determined in mice of different emotional-stress reaction phenotypes, which were subjected to emotional stress and treated by the selective anxiolytic afobazole. The changes were different in BALB/c and C57BL/6 mice. Afobazole exhibited a significant protector action against a decrease in the brain BDNF level caused by emotional stress in BALB/c mice.
在不同情绪应激反应表型的小鼠中测定了脑结构（海马体、下丘脑、纹状体和额叶皮质）中脑源性神经营养因子（BDNF）含量的变化，这些小鼠遭受了情绪应激并接受了选择性抗焦虑药阿伏唑治疗。BALB/c和C57BL/6小鼠的变化有所不同。阿伏唑对BALB/c小鼠因情绪应激导致的脑BDNF水平降低具有显著的保护作用。
Zotero 插件