Glotzbach S F, Heller H C
Am J Physiol. 1975 Jun;228(6):1880-6. doi: 10.1152/ajplegacy.1975.228.6.1880.
Water-perfused thermodes were chronically implanted around the preoptic nuclei and hypothalamus (POH) of kangaroo rats (Dipodomys ingens). Responses in rate of metabolic heat production to manipulations of POH temperature (Thy) were measured in unanesthetized, unrestrained animals at ambient temperatures of 10, 20, 25, and 30 degreeC. The threshold Thy and the proportionally constant (alpha) for this response consistently decreased as ambient temperature increased, but alpha was not significantly different between any two Ta's. Average values of alpha for the three animals studied ranged between -.0024 W.g minus 1.degree C minus 1 and -.0034 W.g minus1.degree C minus 1. No influence of extrahypothalamic core temperature on the characteristics of the central nervous system regulatory mechanism was observed. Ahypothesis accounting for high POH and low peripheral thermosensitivities in small mammals is presented. An additional finding was that during sleep there is a profound depression or elimination of POH thermosensitivity in this species.
将水灌注式热电极长期植入更格卢鼠（长更格卢鼠）的视前核和下丘脑（POH）周围。在环境温度为10、20、25和30摄氏度时，对未麻醉、未束缚的动物测量了POH温度（Thy）变化时代谢产热速率的反应。随着环境温度升高，该反应的阈值Thy和比例常数（α）持续降低，但在任意两个Ta之间，α没有显著差异。所研究的三只动物的α平均值在-0.0024W·g⁻¹·℃⁻¹和-0.0034W·g⁻¹·℃⁻¹之间。未观察到下丘脑外核心温度对中枢神经系统调节机制特征的影响。提出了一个解释小型哺乳动物POH热敏感性高和外周热敏感性低的假说。另一个发现是，在睡眠期间，该物种的POH热敏感性会出现严重降低或消失。
