Dy Emily C, Harlan David M, Rother Kristina I
Diabetes Branch, National Institutes of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Curr Diab Rep. 2006 Aug;6(4):316-22. doi: 10.1007/s11892-006-0067-y.
Pancreas and islet transplant recipients are monitored using various metabolic and imaging methods. The inaccessibility of the transplanted whole pancreas and of the isolated islets poses specific problems (eg, all assessment techniques are indirect). Although successful pancreas transplantation typically restores normal glucose homeostasis, islet transplantation into the liver does not completely normalize islet hormone secretion and glucose metabolism. Development of better testing strategies, such as direct islet imaging, will significantly advance the field.
胰腺和胰岛移植受者通过各种代谢和成像方法进行监测。移植的全胰腺和分离的胰岛难以接近带来了特定问题(例如,所有评估技术都是间接的)。尽管成功的胰腺移植通常能恢复正常的葡萄糖稳态,但将胰岛移植到肝脏并不能完全使胰岛激素分泌和葡萄糖代谢正常化。开发更好的检测策略,如直接胰岛成像,将显著推动该领域的发展。