Moosa M R, Kidd M
Department of Medicine, Faculty of Health Sciences, University of Stellenbosch and Renal Unit, Tygerberg Academic Hospital, Cape Town, South Africa.
Kidney Int. 2006 Sep;70(6):1107-14. doi: 10.1038/sj.ki.5001750. Epub 2006 Aug 2.
The increasing burden of chronic kidney disease places enormous strains on resources of all countries, but especially of those with emerging economies. Few developing countries are able to afford dialysis programs and those that do ration this scarce resource. In South Africa, rationing has been practiced since the introduction of dialysis. Our renal unit carefully screened patients with end-stage kidney disease (ESKD) based on certain medical and socioeconomic criteria. The outcome of these decisions taken by the Assessment Committee is reviewed in this study. Details of the 2442 patients with ESKD assessed between 1988 and 2003 for the renal replacement program were captured. Using univariate and multivariate analysis, the odds of being accepted for treatment based on several variables were determined. The majority (52.7%) of patients with ESKD were not offered renal replacement therapy in the period of study. The number of kidney transplants progressively decreased, as did the number of patients accepted. The patients mostly likely to be accepted for renal replacement therapy were aged 20-40 years, white, employed, married, non-diabetic, and lived in proximity to a dialysis center. Almost 60% of patients were denied renal replacement treatment because of social factors related to poverty. In a developing country, where rationing of treatment is unavoidable, it is difficult to ensure equity of treatment and certain groups are advantaged over others. In our experience, socioeconomic factors influenced decision to accept patients more profoundly than medical ones.
慢性肾脏病负担的日益加重给各国资源带来了巨大压力,对新兴经济体国家而言尤甚。很少有发展中国家能够负担得起透析项目,即便有也会对这种稀缺资源进行配给。在南非,自透析项目引入以来就一直在实行配给制。我们的肾脏科根据特定的医学和社会经济标准对终末期肾病(ESKD)患者进行了仔细筛查。本研究对评估委员会做出的这些决定的结果进行了审查。记录了1988年至2003年间接受肾脏替代治疗项目评估的2442例ESKD患者的详细信息。通过单变量和多变量分析,确定了基于多个变量被接受治疗的几率。在研究期间,大多数(52.7%)ESKD患者未获得肾脏替代治疗。肾脏移植的数量逐渐减少,被接受治疗的患者数量也同样如此。最有可能被接受肾脏替代治疗的患者年龄在20至40岁之间,为白人,有工作,已婚,非糖尿病患者,且居住在透析中心附近。近60%的患者因与贫困相关的社会因素而被拒绝接受肾脏替代治疗。在一个治疗配给不可避免的发展中国家,很难确保治疗的公平性,某些群体比其他群体更具优势。根据我们的经验,社会经济因素对接受患者的决定影响比医学因素更为深刻。