Al-Maghrabi Jaudah, Kamel-Reid Suzanne, Bailey Denis J
Department of Pathology, King Faisal Specialist Hospital & Research Centre, Jeddah, PO Box 40047, Jeddah 21499, MBC J-10, Kingdom of Saudi Arabia.
Saudi Med J. 2006 Aug;27(8):1125-9.
Epstein-Barr virus (EBV) infection is associated with a diverse group of malignancies and many lymphoproliferative disorders. Castleman's disease (CD) is atypical lymphoproliferative disorder. The role of EBV in the pathogenesis of CD is not clear yet. The objective of this study is to investigate the EBV status in CD.
We searched medical records for cases of CD at the Toronto General Hospital, Toronto, Canada and King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Twenty cases were found. The presence of EBV was analyzed using polymerase chain reaction. Polymerase chain reaction were performed at the Department of Pathology and Laboratory Medicine, Toronto General Hospital. The study started in 2001 and completed in 2005.
The age range was 16-90 years. Seventeen patients manifested the localized form of CD. There were 11 males 9 females. Epstein-Barr virus genome was detected only in 2 cases; both were males and have plasma cell type. One is a localized type and the other is of a multicentric type. One patient revealed clonal rearrangement of the immunoglobulin H.
The number of cases is small; however it appears that EBV is less likely to play a significant role in the pathogenesis of CD; however, it seems to be associated with clonal progression.
爱泼斯坦-巴尔病毒（EBV）感染与多种恶性肿瘤及许多淋巴增殖性疾病相关。卡斯特曼病（CD）是一种非典型淋巴增殖性疾病。EBV在CD发病机制中的作用尚不清楚。本研究的目的是调查CD中的EBV状态。
我们在加拿大多伦多的多伦多综合医院和沙特阿拉伯吉达的阿卜杜勒阿齐兹国王大学医院搜索了CD病例的医疗记录。共发现20例。使用聚合酶链反应分析EBV的存在情况。聚合酶链反应在多伦多综合医院病理与检验医学部进行。该研究于2001年开始，2005年完成。
年龄范围为16至90岁。17例患者表现为局限性CD。男性11例，女性9例。仅在2例中检测到爱泼斯坦-巴尔病毒基因组；这2例均为男性，且为浆细胞型。1例为局限性类型，另1例为多中心型。1例患者显示免疫球蛋白H的克隆重排。
病例数量较少；然而，EBV似乎不太可能在CD的发病机制中起重要作用；不过，它似乎与克隆进展有关。
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