丘脑底核深部脑刺激作为难治性癫痫的辅助治疗方法。
Deep brain stimulation of the subthalamic nucleus as adjunct treatment for refractory epilepsy.
作者信息
Handforth Adrian, DeSalles Antonio A F, Krahl Scott E
机构信息
Department of Neurology, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA.
出版信息
Epilepsia. 2006 Jul;47(7):1239-41. doi: 10.1111/j.1528-1167.2006.00563.x.
PURPOSE
We studied the efficacy and safety of bilateral subthalamic deep brain stimulation (DBS) for refractory partial-onset epilepsy in two cases.
METHODS
This was an open treatment pilot study for subjects who had failed numerous medications and had seizure injuries. Seizure counts and adverse events were collected during a 3-4 month baseline, and for 26-32 months after DBS surgery, with AEDs held constant.
RESULTS
Case 1, age 45, with bitemporal seizures, had about half the seizure frequency but still fell with injuries. Case 2, age 46, with left frontal encephalomalacia, had a frequency reduction of about one-third, but a more meaningful reduction of seizure severity and injuries.
CONCLUSIONS
Subthalamic DBS partly reduced partial-onset seizures, but the quality of life was more affected by seizure-related injuries.
目的
我们研究了双侧丘脑底核深部脑刺激（DBS）治疗两例难治性部分性发作癫痫的疗效和安全性。
方法
这是一项针对多种药物治疗失败且有癫痫发作损伤的受试者的开放性治疗试点研究。在3 - 4个月的基线期以及DBS手术后26 - 32个月收集癫痫发作次数和不良事件，抗癫痫药物（AEDs）保持不变。
结果
病例1，45岁，双侧颞叶癫痫发作，癫痫发作频率约降低一半，但仍会因发作而受伤。病例2，46岁，左额叶脑软化，癫痫发作频率降低约三分之一，但癫痫发作严重程度和受伤情况有更显著的降低。
结论
丘脑底核DBS部分减少了部分性发作癫痫，但生活质量受癫痫相关损伤的影响更大。
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