[先天性心脏病新生儿及婴儿体外循环手术治疗期间的炎症反应介质]

[Inflammatory response mediators in newborns and infants with congenital heart diseases during surgical treatment under extracorporeal circulation].

作者信息

Bokeriia L A, Samuilova D Sh, Averina T B, Samsonova N N, Neshkova E A, Fokina N S, Gurova M M

出版信息

Anesteziol Reanimatol. 2006 May-Jun(3):34-8.

Abstract

Surgical treatment of complex congenital heart disease under extracorporeal circulation is accompanied by a systemic inflammatory reaction occurring in neonatal infants and babies. There were drastic increases in the concentration of tumor necrosis factor, interleukin-8, neutrophilic elastase and a predominance of a proinflammatory response over an inflammatory one at the warming stages and after administration of protamine sulfate. The rate of an inflammatory response depended on the duration of extracorporeal circulation. Modified ultrafiltration could remove cytokines; however, their concentration in the body remains high. A relationship was found between the course of a postoperative period and the rate of a developing reaction to extracorporeal circulation in the surgical treatment of congenital heart diseases.

摘要

体外循环下复杂先天性心脏病的外科治疗会伴随新生儿和婴儿出现全身炎症反应。在复温阶段以及注射硫酸鱼精蛋白后，肿瘤坏死因子、白细胞介素-8、中性粒细胞弹性蛋白酶的浓度急剧升高，且促炎反应占主导地位。炎症反应的速率取决于体外循环的持续时间。改良超滤可清除细胞因子；然而，它们在体内的浓度仍保持在较高水平。在先天性心脏病的外科治疗中，发现术后病程与体外循环反应的发展速率之间存在关联。