侧链修饰的埃坡霉素类似物的构效关系——氮原子的位置有多重要？ - Suppr

Structure-activity relationships in side-chain-modified epothilone analogues--how important is the position of the nitrogen atom?

作者信息

Bold Guido, Wojeik Séverine, Caravatti Giorgio, Lindauer Renate, Stierlin Claire, Gertsch Jürg, Wartmann Markus, Altmann Karl-Heinz

机构信息

Global Discovery Chemistry, Novartis Institute for Biomedical Research, Basel, Switzerland.

出版信息

ChemMedChem. 2006 Jan;1(1):37-40. doi: 10.1002/cmdc.200500051.

DOI:10.1002/cmdc.200500051

PMID:16892331

Abstract

摘要

相似文献

Structure-activity relationships in side-chain-modified epothilone analogues--how important is the position of the nitrogen atom?

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Five new epothilone metabolites from Sorangium cellulosum strain So0157-2.

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ChemMedChem. 2006 Jan;1(1):41-4. doi: 10.1002/cmdc.200500056.

Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A.

Bioorg Med Chem Lett. 2009 Jul 15;19(14):3760-3. doi: 10.1016/j.bmcl.2009.04.112. Epub 2009 May 3.

Stereoselective synthesis of 12,13-cyclopropyl-epothilone B and side-chain-modified variants.

Org Lett. 2011 Mar 18;13(6):1436-9. doi: 10.1021/ol200114k. Epub 2011 Feb 21.

引用本文的文献

Total synthesis and selective activity of a new class of conformationally restrained epothilones.

Chemistry. 2008;14(2):570-81. doi: 10.1002/chem.200701143.

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Structure-activity relationships in side-chain-modified epothilone analogues--how important is the position of the nitrogen atom?

作者信息

Bold Guido, Wojeik Séverine, Caravatti Giorgio, Lindauer Renate, Stierlin Claire, Gertsch Jürg, Wartmann Markus, Altmann Karl-Heinz

机构信息

Global Discovery Chemistry, Novartis Institute for Biomedical Research, Basel, Switzerland.

出版信息

ChemMedChem. 2006 Jan;1(1):37-40. doi: 10.1002/cmdc.200500051.

DOI:10.1002/cmdc.200500051

PMID:16892331

Abstract

摘要

相似文献

Structure-activity relationships in side-chain-modified epothilone analogues--how important is the position of the nitrogen atom?

ChemMedChem. 2006 Jan;1(1):37-40. doi: 10.1002/cmdc.200500051.

The binding mode of side chain- and C3-modified epothilones to tubulin.

ChemMedChem. 2010 Jun 7;5(6):911-20. doi: 10.1002/cmdc.201000050.

Conformation-activity relationships in polyketide natural products. Towards the biologically active conformation of epothilone.

Org Biomol Chem. 2004 Jan 7;2(1):127-32. doi: 10.1039/b312213c. Epub 2003 Nov 20.

Conformation-activity relationships in polyketide natural products: a new perspective on the rational design of epothilone analogues.

J Am Chem Soc. 2003 Jan 8;125(1):26-7. doi: 10.1021/ja028196l.

Epothilones as lead structures for the synthesis-based discovery of new chemotypes for microtubule stabilization.

Acc Chem Res. 2008 Jan;41(1):21-31. doi: 10.1021/ar700157x. Epub 2007 Dec 27.

The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents.

Angew Chem Int Ed Engl. 2003 Jun 6;42(22):2511-5. doi: 10.1002/anie.200351276.

Five new epothilone metabolites from Sorangium cellulosum strain So0157-2.

J Antibiot (Tokyo). 2009 Sep;62(9):483-7. doi: 10.1038/ja.2009.55. Epub 2009 Jul 3.

Molecular design and chemical synthesis of a highly potent epothilone.

ChemMedChem. 2006 Jan;1(1):41-4. doi: 10.1002/cmdc.200500056.

Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A.

Bioorg Med Chem Lett. 2009 Jul 15;19(14):3760-3. doi: 10.1016/j.bmcl.2009.04.112. Epub 2009 May 3.

Stereoselective synthesis of 12,13-cyclopropyl-epothilone B and side-chain-modified variants.

Org Lett. 2011 Mar 18;13(6):1436-9. doi: 10.1021/ol200114k. Epub 2011 Feb 21.

引用本文的文献

Total synthesis and selective activity of a new class of conformationally restrained epothilones.

Chemistry. 2008;14(2):570-81. doi: 10.1002/chem.200701143.

Structure-activity relationships in side-chain-modified epothilone analogues--how important is the position of the nitrogen atom?

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Structure-activity relationships in side-chain-modified epothilone analogues--how important is the position of the nitrogen atom?

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