Nishiyama Yoshihiro, Yamamoto Yuka, Monden Toshihide, Sasakawa Yasuhiro, Kawai Nobuyuki, Satoh Katashi, Ohkawa Motoomi
Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
Eur J Nucl Med Mol Imaging. 2007 Jan;34(1):78-86. doi: 10.1007/s00259-006-0153-z. Epub 2006 Jul 29.
The purpose of this study was to investigate the accumulation of FDG in immunocompetent patients with primary central nervous system (CNS) lymphoma using qualitative and quantitative PET images and to compare baseline with follow-up PET after therapy.
Twelve immunocompetent patients with CNS lymphoma were examined. Dynamic emission data were acquired for 60 min immediately following injection of FDG. In seven patients, repeated PET studies were performed after treatment. Applying a three-compartment five-parameter model, K (1), k (2), k (3), k (4), vascular fraction (V ( B )) and cerebral metabolic rate of glucose (CMR(Glc)) were obtained. We evaluated the FDG uptake visually using qualitative and parametric images and quantitatively using parametric images.
A total of 12 lesions were identified in ten patients with newly diagnosed CNS lymphoma. On visual analysis, ten lesions showed an increase on qualitative images, eight showed an increase on K (1) images, 12 showed an increase on k (3) images and ten showed an increase on CMR(Glc) images. On quantitative analysis, k (2), k (3) and CMR(Glc) values of the lesion were significantly different from those of the normal grey matter (p<0.02-0.0005). A total of three lesions were identified in two patients with recurrent tumour. All three lesions showed an increase on qualitative, k (3) and CMR(Glc) images. The K (1), k (2), k (3) and CMR(Glc) values after treatment were significantly different from those obtained before treatment (p<0.04-0.008).
Kinetic analysis, especially with respect to k (3), using dynamic FDG PET might be helpful for diagnosis of CNS lymphoma and for monitoring therapeutic assessment.
本研究旨在利用定性和定量PET图像，研究免疫功能正常的原发性中枢神经系统（CNS）淋巴瘤患者体内FDG的蓄积情况，并比较治疗前与治疗后随访PET的结果。
对12例免疫功能正常的CNS淋巴瘤患者进行检查。注射FDG后立即采集60分钟的动态发射数据。7例患者在治疗后进行了重复PET研究。应用三室五参数模型，获得K（1）、k（2）、k（3）、k（4）、血管分数（V（B））和脑葡萄糖代谢率（CMR（Glc））。我们使用定性和参数图像对FDG摄取进行视觉评估，并使用参数图像进行定量评估。
10例新诊断的CNS淋巴瘤患者共发现12个病灶。视觉分析显示，10个病灶在定性图像上表现为摄取增加，8个在K（1）图像上增加，12个在k（3）图像上增加，10个在CMR（Glc）图像上增加。定量分析显示，病灶的k（2）、k（3）和CMR（Glc）值与正常灰质显著不同（p<0.02-0.0005）。2例复发肿瘤患者共发现3个病灶。所有3个病灶在定性、k（3）和CMR（Glc）图像上均表现为摄取增加。治疗后的K（1）、k（2）、k（3）和CMR（Glc）值与治疗前显著不同（p<0.04-0.008）。
动态FDG PET的动力学分析，尤其是关于k（3）的分析，可能有助于CNS淋巴瘤的诊断和治疗评估监测。
Zotero 插件