Feuerecker M S, Daunderer M, Pape N-B, Kuhnle G E H
Klinik für Anästhesiologie, Ludwig-Maximilians-Universität, Marchioninistr. 15, 81377 München.
Anaesthesist. 2006 Oct;55(10):1058-63. doi: 10.1007/s00101-006-1060-1.
Intraoperative wakefulness is not only limited to adults and can also be found at a similar percentage (0.8%) in paediatric anaesthesia. For prevention of awareness neurophysiologic methods like auditory evoked potentials might be helpful. We report a case of a 2-year-old boy receiving balanced anaesthesia with sevoflurane and alfentanil. Midlatency auditory evoked potentials (MLAEPs) were recorded continuously before, during and after the surgical procedure. During the surgical procedure sevoflurane was withdrawn unintentionally. After a short period of time the boy started coughing and moved his legs, which was interpreted as insufficient analgesia. Several boli of alfentanil did not lead to the expected clinical effect on the depth of anaesthesia. After a recheck of the anaesthetic ventilator the error was determined and delivery of the volatile anaesthetic restored. The postoperative evaluation of the MLAEPs revealed the inadequate suppression of auditory processing during this incident with latencies comparable to the awake state. After reapplication of sevoflurane the MLAEPs were almost completely suppressed demonstrating adequate anesthetic depth. Exemplarily this case suggests that MLAEPs could be used to detect intraoperative awareness also in paediatric anaesthesia. Investigations to prove the validity and reproducibility of MLAEPs in children will be necessary.
术中知晓不仅限于成人,在小儿麻醉中也有类似比例(0.8%)的情况发生。对于预防术中知晓,像听觉诱发电位这样的神经生理学方法可能会有所帮助。我们报告一例2岁男孩,接受七氟烷和阿芬太尼的平衡麻醉。在手术过程的前、中、后持续记录中潜伏期听觉诱发电位(MLAEPs)。手术过程中七氟烷意外停供。短时间后男孩开始咳嗽并移动双腿,这被解释为镇痛不足。多次推注阿芬太尼并未对麻醉深度产生预期的临床效果。在重新检查麻醉呼吸机后确定了错误,并恢复了挥发性麻醉剂的供应。术后对MLAEPs的评估显示,在此事件中听觉处理抑制不足,潜伏期与清醒状态相当。重新应用七氟烷后,MLAEPs几乎完全被抑制,表明麻醉深度足够。该病例示例性地表明,MLAEPs也可用于检测小儿麻醉中的术中知晓。有必要进行研究以证明MLAEPs在儿童中的有效性和可重复性。