Tsukuda Mamoru, Ishitoya Junichi, Mikami Yasukazu, Matsuda Hideki, Katori Hideaki, Horiuchi Choichi, Taguchi Takahide, Yoshida Takafumi, Toth Gabor
Dept. of Biology and Function in the Head and Neck, Yokohama City University Graduate School of Medicine, Japan.
Gan To Kagaku Ryoho. 2006 Jun;33 Suppl 1:172-8.
Most cases of head and neck squamous cell carcinoma (HNSCC) are in the advanced stages, resulting in a poor prognosis. To improve the poor outcome, adjuvant chemotherapy is indispensable for advanced cases with a high relapse risk after standard definitive treatments including surgery and/or radiotherapy. To define an adequate administration schedule in adjuvant chemotherapy with S-1, a controlled randomized study in multi-institutes was done. The results showed the 2-week administration followed by 1-week rest was superior to the 4-week administration followed by the 2-week rest in terms of safety and efficacy. In the present paper, some problems of adjuvant chemotherapy were discussed, and the protocol was described in terms of a multi-institutional controlled randomized comparison study of S-1 versus UFT in an adjuvant chemotherapy setting for locally advanced HNSCC.
大多数头颈部鳞状细胞癌（HNSCC）病例处于晚期，导致预后不良。为改善这种不良结局，对于在包括手术和/或放疗在内的标准确定性治疗后具有高复发风险的晚期病例，辅助化疗必不可少。为确定S-1辅助化疗的合适给药方案，开展了一项多机构对照随机研究。结果显示，在安全性和有效性方面，2周给药后休息1周优于4周给药后休息2周。在本文中，讨论了辅助化疗的一些问题，并根据一项在局部晚期HNSCC辅助化疗中比较S-1与优福定的多机构对照随机研究描述了方案。
