Sladowska Joanna, Wierzbicka Aldona, Litwin Mieczysław, Antoniewicz Jolanta, Niemirska Anna, Wawer Zbigniew, Socha Piotr, Skorupa Ewa, Grenda Ryszard
Instytut Pomnik-Centrum Zdrowia Dziecka.
Przegl Lek. 2006;63 Suppl 3:107-10.
Hypertensive arteriopathy and intima-media (IMT) thickening is observed already in adolescents with primary hypertension (PH) at diagnosis. The injury of arterial wall may cause also generation of free radicals and free radicals may by itself perpetuate arterial wall injury. The aim of the study was to verify the hypothesis that children with PH are exposed to oxidative injury (Sox) due to impaired antioxidant barrier, and that markers of Sox correlate with IMT and metabolic risk factors of arteriosclerosis.
controlled, cross-sectional.
76 children with untreated PH, aged 14.7 yrs (5-20): 23 girls, 53 boys.
83 healthy children aged 13.4 yrs (4-23): 44 girls, 39 boys.
Sono-graphic assessment of IMT in common carotid (cIMT) and superficial femoral arteries (cIMT). Sox was assessed as thiobarbituric acid reactive substances plasma concentration (TBARS), glutathione plasma concentration (GSH) as well as, glutathione peroxidase activity (GPX) were tested to demonstrate free radical scavenger activity.
PH pts had greater cIMT (p<0.0001), carotid wall cross sectional area (WCSA) (p<0.0001), fIMT (p<0.0001), lower HDL-cholesterol, apoA1/apoB than control group (p<0.05). GSH and GPX did not differ between groups but TBARS was significantly greater in PH pts (p <0.05). In control group fIMT significantly correlated with hCRP (r=0.30, p<0.01), homocysteine (r=0.3, p< 0.05), apoA1 (r=-0.2417, p<0.05), TBARS (r=0.329, p<0.01), GPX (r=-0.241, p<0.05) and with GSH (r=-0.22, p=0.05). In pts group, there were similar correlations between fIMT and hCRP (r=0.29, p<0.05), apoA1/apoB (r=-0.28, p<0.05).
PH pts are exposed to significantly higher Sox than controls. The significant correlations between markers of Sox and biochemical parameters suggest that hypertensive arteriopathy is an effect of complex interplay between Sox, metabolic and hemodynamic insults.
在原发性高血压（PH）青少年患者确诊时即可观察到高血压性动脉病变和内膜中层（IMT）增厚。动脉壁损伤也可能导致自由基生成，而自由基本身可能会使动脉壁损伤持续存在。本研究的目的是验证以下假设：PH患儿由于抗氧化屏障受损而遭受氧化损伤（Sox），且Sox标志物与IMT及动脉硬化的代谢危险因素相关。
对照、横断面研究。
76例未经治疗的PH患儿，年龄14.7岁（5 - 20岁）：23例女孩，53例男孩。
83例健康儿童，年龄13.4岁（4 - 23岁）：44例女孩，39例男孩。
对颈总动脉（cIMT）和股浅动脉进行超声评估IMT。通过检测硫代巴比妥酸反应性物质血浆浓度（TBARS）评估Sox，检测谷胱甘肽血浆浓度（GSH）以及谷胱甘肽过氧化物酶活性（GPX）以证明自由基清除活性。
PH患者的cIMT（p<0.0001）、颈动脉壁横截面积（WCSA）（p<0.0001）、fIMT（p<0.0001）更大，高密度脂蛋白胆固醇、载脂蛋白A1/载脂蛋白B低于对照组（p<0.05）。两组间GSH和GPX无差异，但PH患者的TBARS显著更高（p <0.05）。在对照组中，fIMT与高敏C反应蛋白（hCRP）（r = 0.30，p<0.01）、同型半胱氨酸（r = 0.3，p<0.05）、载脂蛋白A1（r = -0.2417，p<0.05）、TBARS（r = 0.329，p<0.01）、GPX（r = -0.241，p<0.05）以及GSH（r = -0.22，p = 0.05）显著相关。在患者组中，fIMT与hCRP（r = 0.29，p<0.05）、载脂蛋白A1/载脂蛋白B（r = -0.28，p<0.05）之间存在类似的相关性。
PH患者遭受的Sox显著高于对照组。Sox标志物与生化参数之间的显著相关性表明，高血压性动脉病变是Sox、代谢和血流动力学损伤之间复杂相互作用的结果。
Zotero 插件