Simple synthesis of novel acyclic (e)-bromovinyl nucleosides as potential antiviral agents.
作者信息
Kim Jin Woo, Hong Joon Hee
机构信息
College of Pharmacy, Chosun University, Kwangju, Republic of Korea.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2006;25(8):879-87. doi: 10.1080/15257770600793877.
PMID:16901820
Abstract
In these study, novel acyclic (E)-bromovinyl nucleosides were synthesized as potential antiviral agents. The coupling of the allylic bromide 9 with bases (thymine, uracil, 5-fluorouracil, 5-iodouracil, cytosine, adenine) afforded a series of novel acyclic nucleosides. The synthesized compounds were evaluated for their antiviral activity against various viruses such as HIV-1, HSV-1, HSV-2, and HCMV. 5-Iodouracil analogue 19 showed weak anti-HIV-1 activity.
摘要
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