Choi Sun Shim, Vallender Eric J, Lahn Bruce T
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, USA.
Mol Biol Evol. 2006 Nov;23(11):2131-3. doi: 10.1093/molbev/msl086. Epub 2006 Aug 10.
The 3-dimensional (3D) structural context of amino acid residues in a protein could significantly impact the level of selective constraint on the residues. Here, by analyzing 767 mammalian proteins, we systematically investigate how various 3D structural contexts influence selective constraint. The structural contexts we examined include solvent accessibility, secondary structure, and intramolecular residue-residue interactions. Through this analysis, we offer quantitative information on how 3D structural contexts affect the level of selective constraint.
蛋白质中氨基酸残基的三维（3D）结构背景可能会显著影响对这些残基的选择性约束水平。在此，通过分析767种哺乳动物蛋白质，我们系统地研究了各种3D结构背景如何影响选择性约束。我们研究的结构背景包括溶剂可及性、二级结构和分子内残基-残基相互作用。通过这项分析，我们提供了关于3D结构背景如何影响选择性约束水平的定量信息。
