Hafner Christian, Hohenleutner Ulrich, Babilas Philipp, Landthaler Michael, Vogt Thomas
Klinik und Poliklinik fur Dermatologie, Universitat Regensburg, Germany.
Dermatology. 2006;213(2):163-5. doi: 10.1159/000093860.
Cutaneous plasmacytosis is a rare disease predominantly found in Japanese patients. We describe the case of a 75-year-old white female with cutaneous plasmacytosis of the face and involvement of the bone marrow. In contrast to other cases of cutaneous plasmacytosis, the patient revealed hypogammaglobulinemia and elevated levels of free light chains in the urine. Treatment with topical pimecrolimus 1%, which primarily targets T cells, led to almost complete clinical and histological remission of the skin lesions. Our report indicates that the therapeutically induced disappearance of the plasma cells was due to indirect T-cell-mediated effects.
皮肤浆细胞增多症是一种罕见疾病，主要见于日本患者。我们报告一例75岁白人女性面部皮肤浆细胞增多症伴骨髓受累的病例。与其他皮肤浆细胞增多症病例不同，该患者出现低丙种球蛋白血症及尿中游离轻链水平升高。使用主要作用于T细胞的1%吡美莫司局部治疗，使皮肤病变几乎完全获得临床及组织学缓解。我们的报告表明，治疗诱导的浆细胞消失是由于间接的T细胞介导效应。
