Ushijima Kentarou, Morikawa Takuya, To Hideto, Higuchi Shun, Ohdo Shigehiro
Clinical Pharmacokinetics, Division of Clinical Pharmacy, Department of Medico-pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Behav Brain Res. 2006 Oct 16;173(2):326-30. doi: 10.1016/j.bbr.2006.06.038. Epub 2006 Aug 14.
The chronic mild stress (CMS) model has been established as a realistic model of depressive disorder as it simulates anhedonia. In the present study, the consumption of sucrose solution was decreased in the rats exposed to CMS, which coincided with many published studies. Since depression is a multifaceted disorder, and a number of symptoms may be present, including circadian rhythm disturbances, we attempted to find the chronobiological abnormalities in CMS rats. After 4-week of the stress procedure, the rhythmic pattern of rectal temperature in the CMS group was extinguished. In particular, the temperature in the CMS group in the light phase was significantly higher than that in the control group. The plasma corticosterone levels in the CMS group were remarkably increased in the light phase compared to the control group, but not in the dark phase. It was concluded that the CMS procedure caused the disturbance of circadian rhythms with hyperthermia and hypercortisolism.
慢性轻度应激（CMS）模型已被确立为一种模拟快感缺乏的抑郁症现实模型。在本研究中，暴露于CMS的大鼠蔗糖溶液消耗量减少，这与许多已发表的研究一致。由于抑郁症是一种多方面的疾病，可能存在多种症状，包括昼夜节律紊乱，我们试图在CMS大鼠中发现生物钟异常。经过4周的应激程序后，CMS组直肠温度的节律模式消失。特别是，CMS组在光照期的温度显著高于对照组。与对照组相比，CMS组在光照期的血浆皮质酮水平显著升高，但在黑暗期则没有。得出的结论是，CMS程序导致了伴有体温过高和皮质醇增多症的昼夜节律紊乱。
