The history of subcutaneous oxygen therapy.

Soon after the discovery of oxygen, experiments began on the use of oxygen for therapeutic purposes, including subcutaneous administration of oxygen, on humans and animals. The history of subcutaneous oxygen therapy (SQOT) is examined in the context of the growing understanding of the use and methods of oxygen administration. Little was written about this therapy until the 19th century, despite an advocacy for its use in some circles. There was resurgence in the use of SQOT in the early 20th century. Investigators in the field of anesthesia, including such notable figures as Paul M. Wood, Ralph M. Waters, and John Henry Evans, contributed to the growth in popularity of the therapy and to the literature on the subject. Although SQOT has been supplanted by other means of administration, it may have a role in management of some inflammatory or pain conditions.