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[蛋白水解酶及其抑制剂系统在Wistar大鼠卵巢肿瘤发病机制中的作用以及纠正所检测到的紊乱的可能性]

[The role of the system of proteolytic enzymes and their inhibitors in the pathogenesis of ovarian tumors in Wistar rats and the possibilities for correcting the disorders detected].

作者信息

Zaporozhan V N, Shchurko N I

出版信息

Eksp Onkol. 1990;12(2):36-8.

PMID:1690633
Abstract

The system of proteolytic enzymes and their inhibitors was studied in tissues of ovarian tumours of Wistar rats. It has been revealed that activation of proteolysis enzymes is observed in the genesis of tumour growth against a background of the absence of protease inhibitors. The correction of revealed disturbances by introducing the inhibitors of proteolytic enzymes and hormone preparations has shown that contrical and norcolute are the most effective. The results obtained suggest the further search of preparation normalizing the condition of the given system.

摘要

对Wistar大鼠卵巢肿瘤组织中的蛋白水解酶及其抑制剂系统进行了研究。结果显示,在蛋白酶抑制剂缺乏的背景下,肿瘤生长过程中观察到蛋白水解酶的激活。通过引入蛋白水解酶抑制剂和激素制剂来纠正所发现的紊乱情况,结果表明康力龙和炔诺酮最为有效。所获得的结果表明需要进一步寻找能够使该系统状况正常化的制剂。

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