人类干细胞表面抗原CD34基因在1号染色体上的定位。
Chromosome 1 localization of the gene for CD34, a surface antigen of human stem cells.
作者信息
Tenen D G, Satterthwaite A B, Borson R, Simmons D, Eddy R L, Shows T B
机构信息
Hematology/Oncology Division, Beth Israel Hospital, Boston, MA 02215.
出版信息
Cytogenet Cell Genet. 1990;53(1):55-7. doi: 10.1159/000132894.
PMID:1691071
Abstract
CD34 is a surface antigen expressed on normal human hematopoietic stem cells, as well as on the blast cells of many patients with both lymphocytic and myelocytic leukemias. By Southern blot analysis of DNA from a panel of human x mouse somatic cell hybrids using a CD34 cDNA probe, we demonstrate that the gene for CD34 is located on human chromosome 1 in the 1q12----qter region.
摘要
CD34是一种在正常人类造血干细胞以及许多淋巴细胞性和髓细胞性白血病患者的原始细胞上表达的表面抗原。通过使用CD34 cDNA探针，对一组人x小鼠体细胞杂种的DNA进行Southern印迹分析，我们证明CD34基因位于人类1号染色体的1q12----qter区域。
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