基于递归推导的蛋白质折叠熵准则：六个残基片段作为基本蛋白质单元

Entropic criteria for protein folding derived from recurrences: six residues patch as the basic protein word.

作者信息

Zbilut Joseph P, Chua Gek Huey, Krishnan Arun, Bossa Cecilia, Colafranceschi Mauro, Giuliani Alessandro

机构信息

Department of Molecular Biophysics and Physiology, Rush University Medical Center, 1653 W. Congress Parkway, Chicago, IL 60612, USA.

出版信息

FEBS Lett. 2006 Sep 4;580(20):4861-4. doi: 10.1016/j.febslet.2006.07.076. Epub 2006 Aug 8.

DOI:10.1016/j.febslet.2006.07.076

PMID:16914149

Abstract

Some research has suggested that patches of six constitute an important amino acid window length in proteins for conveying information. We present database evidence that supports this conjecture, as well as additional recurrence-based data that characterization and quantification of these words affect the folding/aggregation features of proteins. Other indirect evidence is presented and discussed.

摘要

一些研究表明，由六个氨基酸组成的片段是蛋白质中传递信息的重要氨基酸窗口长度。我们提供了支持这一推测的数据库证据，以及基于重复出现的额外数据，这些数据表明对这些氨基酸片段的表征和量化会影响蛋白质的折叠/聚集特性。还展示并讨论了其他间接证据。