Vidiri A, Carapella C M, Pace A, Mirri A, Fabi A, Carosi M, Giannarelli D, Pompili A, Jandolo B, Occhipinti E, Di Giovanni S, Crecco M
Department of Diagnostic Imaging, Regina Elena Cancer Institute, Rome, Italy.
J Exp Clin Cancer Res. 2006 Jun;25(2):177-82.
Forty-seven patients with Glioblastoma (42) and Anaplastic Astrocytoma (5) were studied with MR 24 hrs after surgery. In order to evaluate the role of early MR in defining the extent of surgical resection and its relation with the prognosis of malignant glioma patients, three categories of surgical resection were considered: gross total, sub-total and partial resection. The results were correlated with progression-free survival (PFS) and overall survival (ST). As demonstrated by early-MR, gross total resection was performed in 17 patients, sub-total and partial resection in 19 and 11 patients, respectively. The PFS was 6 months in gross total resection, 6 and 3 months in sub-total and in partial resection, respectively. The median survival time was 16 months in total resection patients, 13 months and 7 months in sub-total resection and partial resection patients, respectively. The study confirms that early-MR has to be considered an accurate technique for monitoring the extension of malignant glioma surgical resection and shows a good correlation between early-MR findings, PFS and ST.
47例胶质母细胞瘤患者（42例）和间变性星形细胞瘤患者（5例）在术后24小时接受了磁共振成像（MR）检查。为了评估早期MR在确定手术切除范围及其与恶性胶质瘤患者预后关系中的作用，考虑了三类手术切除：全切除、次全切除和部分切除。结果与无进展生存期（PFS）和总生存期（ST）相关。如早期MR所示，17例患者进行了全切除，19例和11例患者分别进行了次全切除和部分切除。全切除患者的PFS为6个月，次全切除和部分切除患者的PFS分别为6个月和3个月。全切除患者的中位生存时间为16个月，次全切除和部分切除患者的中位生存时间分别为13个月和7个月。该研究证实，早期MR必须被视为监测恶性胶质瘤手术切除范围的准确技术，并且早期MR结果、PFS和ST之间显示出良好的相关性。
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