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11例老年患者的大脑胶质瘤病治疗

Gliomatosis cerebri treatment in 11 elderly patients.

作者信息

Piccirilli M, Landi A, Salvati M

机构信息

Department of Neurosurgical Sciences, University of Rome La Sapienza, Rome, Italy.

出版信息

J Exp Clin Cancer Res. 2006 Jun;25(2):183-7.

Abstract

The Authors report their experience in the treatment of eleven patients over 70 years old (range from 70 to 83, average age 74.8, 7 males and 4 females), with histologically proven diagnosis of glioblastoma multiforme. The GC golden standard treatment is still debated, particularly in elderly patients. All the patients underwent a first line treament with chemotherapy (Temozolomide), followed by Whole Brain Radiotherapy (WBRT) and PCV schedule without Vincristine in case of progression of the disease. The median survival was 16.3 months, ranging from 13 to 22 months. According to our experience, elderly patients should undergo the same treatment of younger patients, provided they are in good health conditions.

摘要

作者报告了他们治疗11例70岁以上患者(年龄范围70至83岁,平均年龄74.8岁,7例男性,4例女性)的经验,这些患者经组织学证实诊断为多形性胶质母细胞瘤。胶质母细胞瘤的金标准治疗方案仍存在争议,尤其是在老年患者中。所有患者均接受了一线化疗(替莫唑胺),随后进行全脑放疗(WBRT),如果疾病进展则采用不含长春新碱的PCV方案。中位生存期为16.3个月,范围为13至22个月。根据我们的经验,老年患者如果健康状况良好,应接受与年轻患者相同的治疗。

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