组胺H4受体在抗炎治疗中的新作用。

The emerging role of the histamine H4 receptor in anti-inflammatory therapy.

作者信息

Lim Herman D, Smits Rogier A, Leurs Rob, De Esch Iwan J P

机构信息

Division of Medicinal Chemistry, Faculty of Sciences, Leiden/Amsterdam Center of Drug Research, LACDR, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.

出版信息

Curr Top Med Chem. 2006;6(13):1365-73. doi: 10.2174/15680266106061365.

DOI:10.2174/15680266106061365

PMID:16918455

Abstract

Antagonists for the Histamine H(1) receptor have been on the market for decades and continue to be successfully used in the treatment of a variety of allergic conditions. The recently discovered histamine H(4) receptor subtype is emerging as a new and complementary target for treating inflammatory conditions. In this review, we describe the receptor protein, its putative role in (patho)physiology and the latest ligands that are being developed to explore the feasibility of the H(4) receptor as a drug target.

摘要

组胺H(1)受体拮抗剂已上市数十年，并仍成功用于治疗多种过敏病症。最近发现的组胺H(4)受体亚型正成为治疗炎症性疾病的一个新的补充靶点。在本综述中，我们描述了该受体蛋白、其在（病理）生理学中的假定作用以及正在开发的用于探索H(4)受体作为药物靶点可行性的最新配体。