在肾毒性血清性肾炎大鼠中，尽管存在低蛋白血症和大量水肿形成，但仍出现进行性血容量过多。

Progressive hypervolemia despite hypoproteinemia and massive edema formation in rats with nephrotoxic serum nephritis.

作者信息

Fujihara C K, Marcondes M, Zatz R

机构信息

Nephrology Unit, University of São Paulo Medical School, Brazil.

出版信息

Ren Physiol Biochem. 1990 Jul-Aug;13(4):206-12. doi: 10.1159/000173355.

DOI:10.1159/000173355

PMID:1691861

Abstract

Blood volume and whole kidney and single nephron function were evaluated 2 and 10 days after nephrotoxic serum nephritis (NSN) induction in Wistar rats. Progressive proteinuria, hypervolemia and edema were observed in NSN rats. Sodium retention was associated with a progressive depression of single nephron glomerular filtration rate and elevated fractional tubular reabsorption rates. Since hypervolemia rather than hypovolemia was observed in this study, edema formation must have been a consequence of intrarenal rather than extrarenal phenomena.

摘要

在Wistar大鼠中，于肾毒性血清性肾炎（NSN）诱导后第2天和第10天评估血容量、全肾及单个肾单位功能。NSN大鼠出现进行性蛋白尿、血容量过多和水肿。钠潴留与单个肾单位肾小球滤过率的进行性降低及肾小管重吸收率升高有关。由于本研究中观察到的是血容量过多而非血容量不足，所以水肿形成必定是肾内而非肾外现象的结果。