内侧颞叶癫痫的扩散张量成像

Diffusion tensor imaging in medial temporal lobe epilepsy.

作者信息

Yu Ai-hong, Li Kun-cheng, Yu Chun-shui, Wang Yu-ping, Xue Su-fang

机构信息

Department of Radiology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China.

出版信息

Chin Med J (Engl). 2006 Aug 5;119(15):1237-41.

PMID:16919181

Abstract

BACKGROUND

Diffusion tensor imaging (DTI) is a noninvasive imaging technique for the assessment of the integrity of cerebral tissues. This study was undertaken to assess the changes of diffusion indices of hippocampal formation (HF) in patients with medial temporal lobe epilepsy (MTLE).

METHODS

Fourteen patients with MTLE and 14 healthy subjects were evaluated. Mean diffusivity (MD) and fractional anisotropy (FA) from the symmetrical-voxel sampling regions of the anterior HF were calculated in all subjects. The MD and FA values were compared across the groups.

RESULTS

No significant differences of MD and FA values were noted between right and left HF in the controls. In the patient group, MD significantly increased in the HF ipsilateral to the lesioned side [(9.27 +/- 1.09) x 10(-4) mm(2)/s], compared with the values in the contralateral HF [(8.20 +/- 0.59) x 10(-4) mm(2)/s] (t = 4.479, P = 0.001) and healthy subjects [(7.58 +/- 0.51) x 10(-4) mm(2)/s] (P < 0.001), but no significant differences were found in FA. When compared with the controls, patients had a significantly higher MD in the contralateral HF (P < 0.05), but the difference in FA was not statistically significant.

CONCLUSIONS

DTI could detect hippocampal abnormality in patients with MTLE. This technique may be helpful for preoperative evaluation of such patients.

摘要

背景

扩散张量成像（DTI）是一种用于评估脑组织完整性的无创成像技术。本研究旨在评估内侧颞叶癫痫（MTLE）患者海马结构（HF）扩散指数的变化。

方法

对14例MTLE患者和14名健康受试者进行评估。计算所有受试者前HF对称体素采样区域的平均扩散率（MD）和分数各向异性（FA）。比较各组的MD和FA值。

结果

对照组左右HF的MD和FA值无显著差异。在患者组中，病变侧同侧HF的MD显著增加[（9.27±1.09）×10⁻⁴mm²/s]，与对侧HF的值[（8.20±0.59）×10⁻⁴mm²/s]相比（t = 4.479，P = 0.001），与健康受试者[（7.58±0.51）×10⁻⁴mm²/s]相比（P < 0.001），但FA无显著差异。与对照组相比，患者对侧HF的MD显著更高（P < 0.05），但FA的差异无统计学意义。