Essa M H, Mangoud A M, Aly M A, el-Adl M, Morsy T A
Department of Pathology, Faculty of Medicine, Zagazig University, Egypt.
J Egypt Soc Parasitol. 1990 Jun;20(1):161-7.
Twenty patients with bladder carcinoma (14 transitional cell carcinoma and six squamous cell carcinoma) and ten controls of (four with bilharzial lesions, three without and three with metaplasia and dysplasia) were subjected to immunocytochemical and immunohistochemical studies. Bladder and urine samples examination were carried out with the high molecular weight cytokeratin and broad spectrum keratin antibodies using peroxidase anti-peroxidase. Cytokeratins of high molecular weight were expressed in all squamous cancer while broad spectrum keratin was positive in 83.3%. The transitional cell carcinoma was positive in 50% with both cytokeratin and broad spectrum keratin. Urine shedded were positive in 83.3% and 66.7% of squamous cell carcinoma with high molecular weight cytokeratin and broad spectrum keratin respectively. However, each of them was positive in 50% of transitional carcinoma, and negative with non-malignant cases except with metaplasia and dysplasia.
对20例膀胱癌患者（14例移行细胞癌和6例鳞状细胞癌）以及10例对照者（4例有血吸虫病病变，3例无病变，3例有化生和发育异常）进行了免疫细胞化学和免疫组织化学研究。使用过氧化物酶抗过氧化物酶，用高分子量细胞角蛋白和广谱角蛋白抗体对膀胱和尿液样本进行检测。高分子量细胞角蛋白在所有鳞状细胞癌中均有表达，而广谱角蛋白阳性率为83.3%。移行细胞癌中细胞角蛋白和广谱角蛋白的阳性率均为50%。鳞状细胞癌尿液脱落物中高分子量细胞角蛋白和广谱角蛋白的阳性率分别为83.3%和66.7%。然而，它们在50%的移行细胞癌中呈阳性，在除化生和发育异常外的非恶性病例中均为阴性。
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