取代的（S）-N-（α-甲基苄基）氮丙啶的便捷合成。
Expedient synthesis of substituted (S)-N-(alpha-methylbenzyl)aziridines.
作者信息
Bew Sean P, Hughes David L, Savic Vladimir, Soapi Katy M, Wilson Martin A
机构信息
School of Chemical Sciences & Pharmacy, University of East Anglia, Norwich, Norfolk, UK.
出版信息
Chem Commun (Camb). 2006 Sep 7(33):3513-5. doi: 10.1039/b606033a. Epub 2006 Jul 11.
DOI:10.1039/b606033a
PMID:16921429
Abstract
We report for the first time that after O-acylation the conjugate addition products of (S)-N-(alpha-methylbenzyl)hydroxylamine undergo an efficient diastereoselective 3-exo-tet ring-closure reaction affording 2- and 2,3-disubstituted-N-alkylaziridines in good to excellent yields.
摘要
我们首次报道，在O-酰化后，(S)-N-(α-甲基苄基)羟胺的共轭加成产物会发生高效的非对映选择性3-外式-四环化反应，以良好至优异的产率得到2-和2,3-二取代的-N-烷基氮丙啶。
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