Najmaii Samira, Redford Daniel, Larson Douglas F
Sarver Heart Center and Department of Medical Pharmacology, College of Medicine, The University of Arizona, Tucson 85724, USA.
J Extra Corpor Technol. 2006 Jun;38(2):168-73.
Cardiopulmonary bypass (CPB) is associated with surgical stress, hypothermia, hyperoxia, enhancement of neuroendocrine outflow, and administration of glucogenic catecholamines that are associated with glucogonolysis and glucogenesis that result in hyperglycemia. The hyperglycemic state during CPB has been associated with adverse outcomes, such as infection, neurological impairment, cardiac dysfunction, prolonged hospitalization, and higher mortality rates. This report justifies vigilant monitoring of blood glucose levels and a rational protocol for the treatment of hyperglycemia of all open heart surgical patients that may improve post-CPB surgical outcomes.
体外循环(CPB)与手术应激、体温过低、高氧血症、神经内分泌流出增强以及给予与糖原分解和糖异生相关的生糖儿茶酚胺有关,这些都会导致高血糖。CPB期间的高血糖状态与不良后果相关,如感染、神经功能损害、心脏功能障碍、住院时间延长和死亡率升高。本报告证明对所有心脏直视手术患者的血糖水平进行密切监测以及采用合理的高血糖治疗方案是合理的,这可能会改善CPB术后的手术结局。