心血管研究中的物种变异性：促肾上腺皮质激素诱导的高血压实例
Species variability in cardiovascular research: the example of adrenocorticotrophin-induced hypertension.
作者信息
Whitworth Judith A, Zhang Yi, Mangos George, Kelly John J
机构信息
The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.
出版信息
Clin Exp Pharmacol Physiol. 2006 Sep;33(9):887-91. doi: 10.1111/j.1440-1681.2006.04460.x.
Abstract
- Lawrie Beilin has contributed greatly to international hypertension research through both animal and human studies. 2. Animals are used in biomedical research to gain insights that can be extrapolated ultimately to humans. 3. A simple experimental manipulation, adrenocorticotrophin (ACTH) administration, has a range of different cardiovascular effects in different species. 4. Caution should be exercised in extrapolating data from animals to humans.
摘要
- 劳里·贝林通过动物研究和人体研究，为国际高血压研究做出了巨大贡献。2. 生物医学研究中使用动物是为了获得最终可外推至人类的见解。3. 一种简单的实验操作，即给予促肾上腺皮质激素（ACTH），在不同物种中会产生一系列不同的心血管效应。4. 将动物数据外推至人类时应谨慎。
Zotero 插件