人神经干细胞和间充质干细胞在体内外分化及行为的比较分析

Comparative analysis of differentiation and behavior of human neural and mesenchymal stem cells in vitro and in vivo.

作者信息

Aleksandrova M A, Sukhikh G T, Chailakhyan R K, Podgornyi O V, Marei M V, Poltavtseva R A, Gerasimov Yu V

机构信息

Institute of Developmental Biology, Russian Academy of Sciences.

出版信息

Bull Exp Biol Med. 2006 Jan;141(1):152-60. doi: 10.1007/s10517-006-0116-1.

DOI:10.1007/s10517-006-0116-1

PMID:16929988

Abstract

Comparative analysis of differentiation of human neural and mesenchymal stem cells in tissue culture and after transplantation into the brain was carried out using the same antibody set. Neural stem cells differentiated into all types of neural cells, are retained after transplantation, migrate, and form reciprocal relationships with the recipient brain. Mesenchymal stem cells were incapable of neural development under conditions of common culturing or after transplantation and retained the fibroblast-like status. Recipient filaments grew into mesenchymal stem cell transplants containing no neural cells due to local changes in the extracellular matrix at the site of transplantation.

摘要

使用相同的抗体组对人神经干细胞和间充质干细胞在组织培养中以及移植到脑内后的分化情况进行了比较分析。神经干细胞分化为所有类型的神经细胞，移植后得以保留，迁移并与受体脑形成相互关系。间充质干细胞在普通培养条件下或移植后无法进行神经发育，并保持成纤维细胞样状态。由于移植部位细胞外基质的局部变化，受体的细丝长入不含神经细胞的间充质干细胞移植体中。