Houvenaeghel G, Buttarelli M, de Troyer J, Carcopino X, Lelièvre L, Tallet A, Goncalves A, Jacquemier J
Service de Chirurgie Oncologique 2, Institut Paoli-Calmettes, 232, Boulevard Sainte-Marguerite, 13273 Marseille Cedex, France.
Cancer Radiother. 2006 Nov;10(6-7):471-6. doi: 10.1016/j.canrad.2006.07.002. Epub 2006 Aug 23.
Standard treatment of locally advanced cervical carcinoma is actually represented by concomitant chemoradiotherapy followed by brachytherapy since several randomised study results in 1999. Surgical resection after concomitant chemoradiotherapy for locally advanced cervical carcinoma is discussed without evidence of benefice on survival and because morbidity. The aim of this study is to discuss surgery after chemoradiotherapy in terms of rate of morbidity and residual tumor, rate of pelvic disease control, overall survival and disease-free survival.
自1999年多项随机研究结果以来,局部晚期宫颈癌的标准治疗实际上是以同步放化疗后行近距离放疗为代表。对于局部晚期宫颈癌,同步放化疗后进行手术切除,尚无证据表明其对生存率有益且存在手术并发症。本研究的目的是从手术并发症和残留肿瘤发生率、盆腔疾病控制率、总生存率和无病生存率方面探讨放化疗后的手术治疗。