帕米膦酸二钠治疗一名血液透析患者的严重高钙血症
Disodium pamidronate for treating severe hypercalcemia in a hemodialysis patient.
作者信息
Trimarchi Hernán, Lombi Fernando, Forrester Mariano, Elizondo Cristina, Sawinski Deirdre, Pereyra Horacio, Freixas Emilio
机构信息
Department of Medicine, Hospital Británico de Buenos Aires, Argentina.
出版信息
Nat Clin Pract Nephrol. 2006 Aug;2(8):459-63; quiz 464. doi: 10.1038/ncpneph0248.
BACKGROUND
A 48-year-old man with a recent diagnosis of multiple myeloma and rapidly progressive oliguric end-stage renal disease requiring hemodialysis, presented with a serum calcium concentration of 3.4 mmol/l (13.6 mg/dl).
INVESTIGATIONS
Serum laboratory analysis, electroencephalogram, MRI of the brain and bone marrow, and kidney biopsies.
DIAGNOSIS
Hypercalcemia secondary to multiple myeloma.
MANAGEMENT
Short-term intravenous disodium pamidronate therapy (30 mg daily) and daily monitoring of serum calcium concentration.
背景
一名48岁男性，近期诊断为多发性骨髓瘤，患有快速进展的少尿型终末期肾病，需要进行血液透析，其血清钙浓度为3.4 mmol/l（13.6 mg/dl）。
检查
血清实验室分析、脑电图、脑部和骨髓MRI以及肾脏活检。
诊断
多发性骨髓瘤继发高钙血症。
治疗
短期静脉注射帕米膦酸钠治疗（每日30 mg）并每日监测血清钙浓度。
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