Mariano M A, Bardon C B
Clinica de Dermatologia, Hospital da Universidade de Coimbra.
Acta Med Port. 1990 Mar-Apr;3(2):101-7.
Fetoscopy and fetal skin biopsy have together played an important role for antenatal diagnosis of various hereditary skin disorders (genodermatoses). The fetus and placenta can be visualized directly and skin biopsy samples can be obtained for light and electron microscopic studies, tissue culture and biochemical analysis. These techniques have been used successfully in the prenatal diagnosis or exclusion of some types of epidermolysis bullosa, ichthyosis, Chediak-Higashi syndrome, oculocutaneous albinism and anhydrotic ectodermal dysplasia in fetuses known to be at risk from these diseases. The purpose of this report is to describe the current methods of fetoscopy and fetal skin biopsy and to review their main dermatological indications. Complications associated with these procedures are also discussed.
胎儿镜检查和胎儿皮肤活检共同在多种遗传性皮肤病（遗传性皮肤病）的产前诊断中发挥了重要作用。可以直接观察胎儿和胎盘，并获取皮肤活检样本用于光镜和电镜研究、组织培养及生化分析。这些技术已成功用于对已知有患某些类型大疱性表皮松解症、鱼鳞病、切迪阿克 - 东综合征、眼皮肤白化病和无汗性外胚层发育不良风险的胎儿进行产前诊断或排除。本报告的目的是描述当前胎儿镜检查和胎儿皮肤活检的方法，并综述其主要的皮肤科适应证。还讨论了与这些操作相关的并发症。
