Ku Bon D, Shin Hee Young, Kim Eun-Joo, Park Key Chung, Seo Sang Won, Na Duk L
Department of Neurology, Kwandong University College of Medicine, Myongji Hospital, Gyeonggi, Korea.
J Clin Neurosci. 2006 Oct;13(8):860-2. doi: 10.1016/j.jocn.2005.10.013. Epub 2006 Aug 28.
Mania is a rare clinical manifestation of delayed anoxic encephalopathy (DAE). Prior case reports on mania after hypoxic injury involved patients with a previous history of mania or depression, potentially reflecting a recurrence of premorbid mood disorders after hypoxia rather than pure secondary mania. Herein, we report a 55-year-old woman with no past history of neurological or psychiatric illness, who developed mania as a symptom of DAE after carbon monoxide intoxication. Brain magnetic resonance imaging showed diffuse white matter lesions, particularly visible in the frontal white matter. This frontal lesion may have prevented frontal inhibition from being transmitted to the basotemporal limbic area, resulting in mania manifested as a burst of limbic activity.
躁狂是迟发性缺氧性脑病（DAE）的一种罕见临床表现。先前关于缺氧性损伤后躁狂的病例报告涉及有躁狂或抑郁病史的患者，这可能反映了缺氧后病前情绪障碍的复发，而非单纯的继发性躁狂。在此，我们报告一名55岁女性，既往无神经或精神疾病史，在一氧化碳中毒后出现躁狂，作为DAE的一种症状。脑磁共振成像显示弥漫性白质病变，在额叶白质中尤为明显。这种额叶病变可能阻止了额叶抑制传递至基底颞叶边缘区，导致躁狂表现为边缘系统活动的爆发。
