细胞内信号通路对心肌肥大的调控

Regulation of cardiac hypertrophy by intracellular signalling pathways.

作者信息

Heineke Joerg, Molkentin Jeffery D

机构信息

Department of Pediatrics, University of Cincinnati, Children's Hospital Medical Center, Division of Molecular Cardiovascular Biology, 3333 Burnet Ave, Cincinnati, Ohio 45229, USA.

出版信息

Nat Rev Mol Cell Biol. 2006 Aug;7(8):589-600. doi: 10.1038/nrm1983.

DOI:10.1038/nrm1983

PMID:16936699

Abstract

The mammalian heart is a dynamic organ that can grow and change to accommodate alterations in its workload. During development and in response to physiological stimuli or pathological insults, the heart undergoes hypertrophic enlargement, which is characterized by an increase in the size of individual cardiac myocytes. Recent findings in genetically modified animal models implicate important intermediate signal-transduction pathways in the coordination of heart growth following physiological and pathological stimulation.

摘要

哺乳动物的心脏是一个动态器官，能够生长并发生变化以适应其工作负荷的改变。在发育过程中以及对生理刺激或病理损伤作出反应时，心脏会发生肥大性增大，其特征是单个心肌细胞的大小增加。在基因改造动物模型中的最新发现表明，在生理和病理刺激后心脏生长的协调过程中，重要的中间信号转导通路发挥着作用。