Dixon Anne E, Shade David M, Cohen Rubin I, Skloot Gwen S, Holbrook Janet T, Smith Lewis J, Lima John J, Allayee Hooman, Irvin Charles G, Wise Robert A
University of Vermont, Burlington, VT 05401, USA.
J Asthma. 2006 Sep;43(7):553-8. doi: 10.1080/02770900600859123.
Obesity is a risk factor for being diagnosed with asthma, but there is conflicting evidence on whether obesity is a risk factor for lung function abnormalities characteristic of asthma. We studied a cohort of 488 subjects, 47% of whom were obese. Obese and non-obese subjects with asthma had similar airflow limitation and bronchodilator responsiveness, but obese participants had increased sleep disturbance and gastroesophageal reflux disease, higher cytokine levels, and a trend towards increased exacerbations when treated with theophylline. Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people.
肥胖是被诊断为哮喘的一个风险因素，但关于肥胖是否是哮喘特征性肺功能异常的风险因素，证据存在矛盾。我们研究了一个由488名受试者组成的队列，其中47%为肥胖者。患有哮喘的肥胖和非肥胖受试者具有相似的气流受限和支气管扩张剂反应性，但肥胖参与者有更多的睡眠障碍和胃食管反流病、更高的细胞因子水平，并且在接受茶碱治疗时病情加重的趋势增加。肥胖和非肥胖哮喘患者有相似的肺功能异常，但合并症和对药物的反应改变可能会显著影响肥胖人群的哮喘控制。
