表达短发夹RNA的小鼠中的毒性为RNA干扰提供了新的见解。

Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi.

作者信息

Snøve Ola, Rossi John J

机构信息

Division of Molecular Biology, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, CA 91101, USA.

出版信息

Genome Biol. 2006;7(8):231. doi: 10.1186/gb-2006-7-8-231.

DOI:10.1186/gb-2006-7-8-231

PMID:16942630

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1779583/

Abstract

Short hairpin RNAs can provide stable gene silencing via RNA interference. Recent studies have shown toxicity in vivo that appears to be related to saturation of the endogenous microRNA pathway. Will these findings limit the therapeutic use of such hairpins?

摘要

短发夹RNA可通过RNA干扰实现稳定的基因沉默。最近的研究表明其在体内具有毒性，这似乎与内源性微小RNA途径的饱和有关。这些发现会限制此类发夹RNA在治疗中的应用吗？

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e183/1779583/3c350d6213cc/gb-2006-7-8-231-1.jpg

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表达短发夹RNA的小鼠中的毒性为RNA干扰提供了新的见解。

Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi.

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表达短发夹RNA的小鼠中的毒性为RNA干扰提供了新的见解。

Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi.

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