Matthias F R, Ditter H
Department of Internal Medicine, Justus Liebig University, Giessen.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1990;117(1):209-18.
30 rabbits received an infusion of lipopolysaccharide B (75 micrograms/kg.h) over 4 hours (groups E, EI, EA; n = 10 each). Saline was given to a control group (C; n = 8). In group EI, prostacyclin (PGI2; 500 ng/kg.min) was given simultaneously to endotoxin. Into group EA animals, aspirin (20 mg/kg) was injected before the endotoxin infusion was started. PGI2 and aspirin both improved survival of animals (6/10 each vs. 2/10 in group E). The drop of platelet counts was significantly reduced by PGI2, while leukocyte depletion was similar in all endotoxin groups. PGI2 preserved the functional capacity of platelets as indicated by collagen stimulated aggregation and thromboxane formation. PGI2 but not aspirin significantly reduced renal fibrin deposition.
30只兔子在4小时内接受脂多糖B输注（75微克/千克·小时）（E组、EI组、EA组；每组n = 10）。对照组（C组；n = 8）给予生理盐水。在EI组中，前列腺素I2（PGI2；500纳克/千克·分钟）与内毒素同时给予。在EA组动物中，在内毒素输注开始前注射阿司匹林（20毫克/千克）。PGI2和阿司匹林均提高了动物的存活率（每组6/10，而E组为2/10）。PGI2显著降低了血小板计数的下降，而所有内毒素组的白细胞减少情况相似。如胶原刺激的聚集和血栓素形成所示，PGI2保留了血小板的功能能力。PGI2而非阿司匹林显著减少了肾脏纤维蛋白沉积。
