精神分裂症中前额叶功能障碍与儿茶酚-O-甲基转移酶（COMT）Val158Met基因型及工作记忆表现的关系
Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performance.
作者信息
Bertolino Alessandro, Caforio Grazia, Petruzzella Vittoria, Latorre Valeria, Rubino Valeria, Dimalta Savino, Torraco Alessandra, Blasi Giuseppe, Quartesan Roberto, Mattay Venkata S, Callicott Joseph H, Weinberger Daniel R, Scarabino Tommaso
机构信息
Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy.
出版信息
Psychiatry Res. 2006 Oct 30;147(2-3):221-6. doi: 10.1016/j.pscychresns.2006.04.001. Epub 2006 Sep 6.
Earlier studies with functional imaging in schizophrenia have demonstrated dysfunction of the dorsolateral prefrontal cortex during working memory. Controlling for behavioral performance and for catechol-O-methyltransferase (COMT) Val158Met genotype, we here demonstrate in a functional magnetic resonance imaging paradigm that patients recruit greater neuronal resources in prefrontal cortex during working memory, suggesting that this phenotype is a core functional trait of the disease. We also replicated earlier findings that the Val allele of the COMT polymorphism is associated with greater engagement of the prefrontal cortex.
早期针对精神分裂症患者进行的功能成像研究表明，在工作记忆过程中背外侧前额叶皮质存在功能障碍。在控制行为表现和儿茶酚-O-甲基转移酶（COMT）Val158Met基因型的情况下，我们在此通过功能磁共振成像范式证明，患者在工作记忆过程中在前额叶皮质募集了更多的神经元资源，这表明该表型是该疾病的核心功能特征。我们还重复了早期的研究结果，即COMT基因多态性的Val等位基因与前额叶皮质的更大参与度相关。
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